Publications from Thorenlab!
2021
Impact of NK Cell Activating Receptor Gene Variants on Receptor Expression and Outcome of Immunotherapy in Acute Myeloid Leukemia.
Hussein BA, Hallner A, Wennström L, Brune M, Martner A, Hellstrand K, Bernson E, Thorén FB
Front Immunol. 2021 Dec 9;12:796072. doi: 10.3389/fimmu.2021.796072. eCollection 2021.
Pubmed Free full text @ Frontiers
Impact of IL-1β and the IL-1R antagonist on relapse risk and survival in AML patients undergoing immunotherapy for remission maintenance. Grauers Wiktorin H, Aydin E, Christenson K, Issdisai N, Thorén FB, Hellstrand K, Martner A.
Oncoimmunology. 2021 Jul 25;10(1):1944538. doi: 10.1080/2162402X.2021.1944538. eCollection 2021.
Pubmed Free full text @ Taylor&Francis
2020
Idelalisib Rescues Natural Killer Cells from Monocyte-Induced Immunosuppression by Inhibiting NOX2-Derived Reactive Oxygen Species
Akhiani AA, Hallner A, Kiffin R, Aydin E, Werlenius O, Aurelius J, Martner A, Thorén FB, Hellstrand K.
Cancer Immunol Res. 2020 Dec;8(12):1532-1541. doi: 10.1158/2326-6066.CIR-20-0055.
Pubmed Full text @ AACR
miRNAs in NK Cell-Based Immune Responses and Cancer Immunotherapy.
Pesce S, Greppi M, Ferretti E, Obino V, Carlomagno S, Rutigliani M, Thoren FB, Sivori S, Castagnola P, Candiani S, Marcenaro E.
Front Cell Dev Biol. 2020 Feb 25;8:119. doi: 10.3389/fcell.2020.00119.
Pubmed Free full text @ Frontiers
Complete remission after the first cycle of induction chemotherapy determines the clinical efficacy of relapse-preventive immunotherapy in acute myeloid leukaemia
Nilsson MS, Hallner A, Brune M, Nilsson S, Thoren FB, Martner A, Hellstrand K
Br J Haematol. 2020 Feb;188(4):e49-e53. doi: 10.1111/bjh.16320.
Pubmed Free full text @ Wiley
Immunotherapy with HDC/IL-2 may be clinically efficacious in acute myeloid leukemia of normal karyotype.
Nilsson MS, Hallner A, Brune M, Nilsson S, Thorén FB, Martner A, Hellstrand K.
Hum Vaccin Immunother. 2020;16(1):109-111. doi: 10.1080/21645515.2019.1636598.
Pubmed Full text @ Taylor&Francis
2019
Downregulation of HLA class I renders inflammatory neutrophils more susceptible to NK cell-induced apoptosis
Bernson E, Christenson K, Pesce S, Pasanen M, Marcenaro E, Sivori S, Thoren FB
Front Immunol. 2019 Oct 15;10:2444. doi: 10.3389/fimmu.2019.02444.
Pubmed Free full text @ Frontiers
Anthracycline-based consolidation may determine outcome of post-consolidation immunotherapy in AML.
Aurelius J, Möllgård L, Kiffin R, Ewald Sander F, Nilsson S, Bergh Thorén F, Hellstrand K, Martner A.
Leuk Lymphoma. 2019 Apr 17:1-8. doi: 10.1080/10428194.2019.1599110.
Pubmed Full text @ Taylor&Francis
The HLA-B -21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia.
Hallner A, Bernson E, Hussein BA, Sander FE, Brune M, Aurelius J, Martner A, Hellstrand K, Thorén FB.
Blood. 2019 Mar 28;133(13):1479-1488. doi: 10.1182/blood-2018-09-874990
Pubmed Full text @ ASH
2018
Immunotherapy and immunosuppression in myeloid leukemia
Hallner A
Dissertation thesis
ISBN: 978-91-7833-201-4
Co-supervisor: Thorén FB
Full text
Cytomegalovirus Serostatus Affects Autoreactive NK Cells and Outcomes of IL2-Based Immunotherapy in Acute Myeloid Leukemia.
Bernson E, Hallner A, Sander FE, Nicklasson M, Nilsson MS, Christenson K, Aydin E, Liljeqvist JÅ, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén FB.
Cancer Immunol Res. 2018 Jul 6. doi: 10.1158/2326-6066.CIR-17-0711.
Pubmed Full text @ AACR
Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of NOX2.
Kiffin R, Grauers Wiktorin H, Nilsson MS, Aurelius J, Aydin E, Lenox B, Nilsson JA, Ståhlberg A, Thorén FB, Hellstrand K, Martner A.
Front Oncol. 2018 Jun 18;8:218. doi: 10.3389/fonc.2018.00218.
Pubmed Free full text @ Frontiers
Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells.
Wenger A, Werlenius K, Hallner A, Thorén FB, Farahmand D, Tisell M, Smits A, Rydenhag B, Jakola AS, Carén H.
Neoplasia. 2018 Jan;20(1):25-31. doi: 10.1016/j.neo.2017.10.006.
Pubmed Free full text @ Elsevier
2017
Impact of NK cell repertoires on immunotherapy in acute myeloid leukemia
Bernson E
Dissertation thesis
ISBN: 978-91-629-0339-8
Main supervisor: Thorén FB
Full text
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Sander FE, Nilsson M, Rydström A, Aurelius J, Riise RE, Movitz C, Bernson E, Kiffin R, Ståhlberg A, Brune M, Foà R, Hellstrand K, Thorén FB, Martner A.
Cancer Immunol Immunother. 2017 Nov;66(11):1473-1484. doi: 10.1007/s00262-017-2040-9.
Pubmed Free full text @ CII
Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia.
Bernson E, Hallner A, Sander FE, Wilsson O, Werlenius O, Rydström A, Kiffin R, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén FB.
Leukemia. 2017 Dec;31(12):2552-2559. doi: 10.1038/leu.2017.151.
Pubmed Free full text @ NPG
The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands.
Pesce S, Thoren FB, Cantoni C, Prato C, Moretta L, Moretta A, Marcenaro E.
Front Immunol. 2017 Apr 28;8:510. doi: 10.3389/fimmu.2017.00510. eCollection 2017.
Pubmed Free full text @ Frontiers
NOX2-dependent immunosuppression in chronic myelomonocytic leukemia.
Aurelius J, Hallner A, Werlenius O, Riise R, Möllgård L, Brune M, Hansson M, Martner A, Thorén FB, Hellstrand K.
J Leukoc Biol. 2017 Aug;102(2):459-466. doi: 10.1189/jlb.5VMA1116-454R. Epub 2017 Mar 14.
Pubmed Full text @ JLB
Dynamics of myeloid cell populations during relapse-preventive immunotherapy in acute myeloid leukemia.
Rydström A, Hallner A, Aurelius J, Sander FE, Bernson E, Kiffin R, Thoren FB, Hellstrand K, Martner A.
J Leukoc Biol. 2017 Aug;102(2):467-474. doi: 10.1189/jlb.5VMA1116-455R
Pubmed Full text @ JLB
2016
Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells.
Werlenius O, Aurelius J, Hallner A, Akhiani AA, Simpanen M, Martner A, Andersson P-O, Hellstrand K, Thorén FB.
Oncotarget. 2016, doi: 10.18632/oncotarget.8769
Pubmed Free full text @ Oncotarget
Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia.
Sander FE, Rydström A, Bernson E, Kiffin R, Riise R, Aurelius J, Anderson H, Brune M, Foà R, Hellstrand K, Thorén FB, Martner A.
Oncotarget. 2016 Feb 16;7(7):7586-96.
Pubmed Free full text @ Oncotarget
Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia
Martner A, Rydstrom A, Riise RE, Aurelius J, Anderson H, Brune M, Foà R, Hellstrand K, Thoren FB.
Oncoimmunology. 2016, 5(1):e1041701.
Pubmed Full text: Taylor & Francis
2015
NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance.
Martner A, Rydström A, Riise RE, Aurelius J, Brune M, Foà R, Hellstrand K, Thorén FB.
Oncotarget. 2015 Dec 15;6(40):42569-74. doi: 10.18632/oncotarget.5559.
Pubmed Free Full text @ Oncotarget
Opposing effects of immunotherapy in melanoma using multisubtype interferon-alpha – can tumor immune escape after immunotherapy accelerate disease progression?
Strannegard O, Thoren FB.
Oncoimmunology.2015, 5(3): e1091147
Pubmed Free full text: Taylor & Francis Free Full text
Immune escape in chronic leukemia
Werlenius O
Dissertation thesis
ISBN: 978-91-628-9528-0
Main supervisor: Thorén FB
Full text
TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.
Riise RE, Bernson E, Aurelius J, Martner A, Pesce S, Della Chiesa M, Marcenaro E, Bylund J, Hellstrand K, Moretta L, Moretta A, Thorén FB.
J Immunol. 2015 Aug 1;195(3):1121-8. doi: 10.4049/jimmunol.1500709.
Pubmed Full text: J Immunol
On the role of innate cell interactions in inflammation and leukemia
Riise RE
Dissertation thesis
ISBN:978-91-628-9382-8
Main supervisor: Thorén FB
Full text
Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase.
Martner A, Wiktorin HG, Lenox B, Ewald Sander F, Aydin E, Aurelius J, Thorén FB, Ståhlberg A, Hermodsson S, Hellstrand K.
J Immunol. 2015 May 15;194(10):5014-21. doi: 10.4049/jimmunol.1402991.
Pubmed Full text: J Immunol Free PMC Article
Immunotherapy with histamine dihydrochloride and low-dose interleukin-2 favors sustained lymphocyte recovery in acute myeloid leukemia.
Hallner A, Aurelius J, Thorén FB, Sander FE, Brune M, Hellstrand K, Martner A.
Eur J Haematol. 2015 Mar;94(3):279-80. doi: 10.1111/ejh.12454.
Pubmed Full text: Eur J Haematol Free full text
2014
Accumulation of regulatory T cells during immunotherapy does not increase relapse risk in acute myeloid leukemia.
Martner, A., Rydstrom, A., Ewald, F., Riise, R.E., Aurelius, J., Brune, M., Foa, R., Hellstrand, K. & Thoren, F.B.
Blood, E-letter, 2014
http://www.bloodjournal.org/content/124/4/638.e-letters
CD20 antibodies induce production and release of reactive oxygen species by neutrophils.
Werlenius, O., Riise, R., Simpanen, M., Aurelius, J., Thoren, F.B.
Blood. 2014;123(25):4001
Pubmed Full text – Blood Free full text
Role of the ERK Pathway for Oxidant-Induced Parthanatos in Human Lymphocytes.
Akhiani, A.A., Werlenius, O., Aurelius, J., Movitz, C., Martner, A., Hellstrand, K. & Thoren, F.B.
PLoS One 9,e89646(2014)
Pubmed Free full text – PLoS One
2013
Late divergence of survival curves in cancer immunotherapy trials: interpretation and implications.
Thoren, F.B., Anderson, H. & Strannegard, O.
Cancer Immunol Immunother. 2013;62:1547
Pubmed Full text – CII Free full text
Immunotherapeutic strategies for relapse control in acute myeloid leukemia.
Martner, A., Thoren, F.B., Aurelius, J. & Hellstrand, K.
Blood Rev 2013;27:209
Pubmed Full text – Blood Rev Free full text
A simple skin blister technique for the study of in vivo transmigration of human leukocytes.
Davidsson, L., Bjorkman, L., Christenson, K., Alsterholm, M., Movitz, C., Thoren, F.B., Karlsson, A., Welin, A. & Bylund, J.
J Immunol Methods 2013;393:8
Pubmed Full text – J Immunol Methods
Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes.
Aurelius, J., Martner, A., Riise, R.E., Romero, A.I., Palmqvist, L., Brune, M., Hellstrand, K. & Thoren, F.B. J Leukoc Biol 93, 155-160 (2013)
Pubmed Free full text – J Leuk Biol.
2012
Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells.
Aurelius, J., Martner, A., Brune, M., Palmqvist, L., Hansson, M., Hellstrand, K. & Thoren, F.B.
Haematologica 2012;97:1904
Pubmed Free full text – Haematologica
Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of apoptosis.
Aurelius, J., Thoren, F.B., Akhiani, A.A., Brune, M., Palmqvist, L., Hansson, M., Hellstrand, K. & Martner, A.
Blood 2012;119:5832
Pubmed Free full text – Blood
Analyzing cell death events in cultured leukocytes.
Christenson, K., Thoren, F.B. & Bylund, J.
Methods in Molecular Biology 844, 65-86 (2012).
Pubmed Full text – Springer Free full text
Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism.
Thoren, F.B., Riise, R.E., Ousback, J., Della Chiesa, M., Alsterholm, M., Marcenaro, E., Pesce, S., Prato, C., Cantoni, C., Bylund, J., Moretta, L. & Moretta, A.
J Immunol 188, 1668-1674 (2012).
Pubmed Full text: J Immunol
2011
Redox Remodeling by Dendritic Cells Protects Antigen-Specific T Cells against Oxidative Stress.
Martner, A., Aurelius, J., Rydstrom, A., Hellstrand, K. & Thoren, F.B. J Immunol 187, 6243-6248 (2011).
Pubmed Full text – J Immunol
Adjuvant interferon: extended follow-up times needed?
Thoren, F.B. & Strannegard, O.
Lancet Oncol 12, 419 (2011).
Pubmed Free full text – Lancet
Age-Related Efficacy of Immunotherapy with Histamine Dihydrochloride and Interleukin-2 for Relapse Prevention in Acute Myeloid Leukemia.
Hellstrand, K., Thoren, F.B., Martner, A., Soderholm, J., Hofmann, W.K., Rowe, J.M. & Brune, M.
Ann Hematol 90, S30-S32 (2011).
Antitumor properties of histamine in vivo.
Thoren, F.B., Aurelius, J. & Martner, A.
Nature medicine 17, 537 (2011).
Pubmed Full text – Nature Free full text
2010
The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor 1.
Thoren, F.B., Karlsson, J., Dahlgren, C. & Forsman, H.
Biochem Pharmacol 80, 389-395 (2010).
Pubmed Full text – Elsevier
[The discussion about Multiferon should go on].
Strannegard, O. & Thoren, F.B.
Lakartidningen 107, 3227; discussion 3227 (2010).
Pubmed Free full text – Läkartidningen
[Underutilization of anticancer agents–an example].
Strannegard, O. & Thoren, F.B.
Lakartidningen 107, 3150; discussion 3150-3151 (2010).
Pubmed Free full text – Läkartidningen
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia.
Martner, A., Thoren, F.B., Aurelius, J., Soderholm, J., Brune, M. & Hellstrand, K.
Expert Rev Hematol 3, 381-391 (2010).
Pubmed Full text – Taylor & Francis
2009
Histamine dihydrochloride and low-dose interleukin-2 as post-consolidation immunotherapy in acute myeloid leukemia.
Thoren, F.B., Romero, A.I., Brune, M. & Hellstrand, K.
Expert Opin Biol Ther 9, 1217-1223 (2009).
Pubmed Full text Free full text
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 in AML.
Romero, A.I., Thoren, F.B., Aurelius, J., Askarieh, G., Brune, M. & Hellstrand, K.
Scand J Immunol 70, 194-205 (2009).
Pubmed Full text – SJI Free full text
2008
[Interferon-alpha can improve the prognosis in high-risk melanoma. Combination of surgery, cytostatics and natural IFN-alpha doubled the survival rate].
Strannegard, O., Thoren, F.B. & Lundgren, E.
Lakartidningen 105, 358-361 (2008).
Pubmed Free full text – Läkartidningen
2007
The CD16-/CD56bright subset of NK cells is resistant to oxidant-induced cell death.
Thoren, F.B., Romero, A.I., Hermodsson, S. & Hellstrand, K.
J Immunol 179, 781-785 (2007).
Pubmed Free full text – JI
Cutting edge: Antioxidative properties of myeloid dendritic cells: protection of T cells and NK cells from oxygen radical-induced inactivation and apoptosis.
Thoren, F.B., Betten, A., Romero, A.I. & Hellstrand, K.
J Immunol 179, 21-25 (2007).
Pubmed Free full text – JI
2006
Oxygen radicals induce poly(ADP-ribose) polymerase-dependent cell death in cytotoxic lymphocytes.
Thoren, F.B., Romero, A.I. & Hellstrand, K.
J Immunol 176, 7301-7307 (2006).
Pubmed Free full text – JI
Long-term survival benefit after adjuvant treatment of cutaneous melanoma with dacarbazine and low dose natural interferon alpha: A controlled, randomised multicentre trial.
Stadler, R., Luger, T., Bieber, T., Kohler, U., Linse, R., Technau, K., Schubert, R., Schroth, K., Vakilzadeh, F., Volkenandt, M., Gollnick, H., Von Eick, H., Thoren, F. & Strannegard, O.
Acta Oncol 45, 389-399 (2006).
Pubmed Full text
NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen species.
Romero, A.I., Thoren, F.B., Brune, M. & Hellstrand, K.
Br J Haematol 132, 91-98 (2006).
Pubmed Full text
Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMN.
Itou, T., Collins, L.V., Thoren, F.B., Dahlgren, C. & Karlsson, A.
Clin Vaccine Immunol 13, 575-583 (2006).
Pubmed Free full text – CVI
2005
A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions.
Bellner, L., Thoren, F., Nygren, E., Liljeqvist, J.A., Karlsson, A. & Eriksson, K.
J Immunol 174, 2235-2241 (2005).
Pubmed Free full text JI
Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP 104).
Asemissen, A.M., Scheibenbogen, C., Letsch, A., Hellstrand, K., Thoren, F., Gehlsen, K., Schmittel, A., Thiel, E. & Keilholz, U.
Clin Cancer Res 11, 290-297 (2005).
Pubmed Free full text – AACR
2004
Activation of cytotoxic lymphocytes by interferon-{alpha}: role of oxygen radical-producing mononuclear phagocytes.
Hansson, M., Romero, A., Thoren, F., Hermodsson, S. & Hellstrand, K.
J Leukoc Biol 76, 1207-1213 (2004).
Pubmed Free full text – JLB
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals.
Thoren, F., Romero, A., Lindh, M., Dahlgren, C. & Hellstrand, K.
J Leukoc Biol 76, 1180-1186 (2004).