Publications from Thorenlab!

Idelalisib Rescues Natural Killer Cells from Monocyte-Induced Immunosuppression by Inhibiting NOX2-Derived Reactive Oxygen Species
Akhiani AA, Hallner A, Kiffin R, Aydin E, Werlenius O, Aurelius J, Martner A, Thorén FB, Hellstrand K.
Cancer Immunol Res. 2020 Dec;8(12):1532-1541. doi: 10.1158/2326-6066.CIR-20-0055.
Pubmed              Full text @ AACR

miRNAs in NK Cell-Based Immune Responses and Cancer Immunotherapy.
Pesce S, Greppi M, Ferretti E, Obino V, Carlomagno S, Rutigliani M, Thoren FB, Sivori S, Castagnola P, Candiani S, Marcenaro E.
Front Cell Dev Biol. 2020 Feb 25;8:119. doi: 10.3389/fcell.2020.00119.
Pubmed               Free full text @ Frontiers

Complete remission after the first cycle of induction chemotherapy determines the clinical efficacy of relapse-preventive immunotherapy in acute myeloid leukaemia
Nilsson MS, Hallner A, Brune M, Nilsson S, Thoren FB, Martner A, Hellstrand K
Br J Haematol. 2020 Feb;188(4):e49-e53. doi: 10.1111/bjh.16320.
Pubmed               Free full text @ Wiley

Immunotherapy with HDC/IL-2 may be clinically efficacious in acute myeloid leukemia of normal karyotype.
Nilsson MS, Hallner A, Brune M, Nilsson S, Thorén FB, Martner A, Hellstrand K.
Hum Vaccin Immunother. 2020;16(1):109-111. doi: 10.1080/21645515.2019.1636598.
Pubmed              Full text @ Taylor&Francis

Downregulation of HLA class I renders inflammatory neutrophils more susceptible to NK cell-induced apoptosis
Bernson E, Christenson K, Pesce S, Pasanen M, Marcenaro E, Sivori S, Thoren FB
Front Immunol. 2019 Oct 15;10:2444. doi: 10.3389/fimmu.2019.02444.
Pubmed              Free full text @ Frontiers

Anthracycline-based consolidation may determine outcome of post-consolidation immunotherapy in AML.
Aurelius J, Möllgård L, Kiffin R, Ewald Sander F, Nilsson S, Bergh Thorén F, Hellstrand K, Martner A.
Leuk Lymphoma. 2019 Apr 17:1-8. doi: 10.1080/10428194.2019.1599110.
Pubmed              Full text @ Taylor&Francis

The HLA-B -21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia.
Hallner A, Bernson E, Hussein BA, Sander FE, Brune M, Aurelius J, Martner A, Hellstrand K, Thorén FB.
Blood. 2019 Mar 28;133(13):1479-1488. doi: 10.1182/blood-2018-09-874990
Pubmed              Full text @ ASH

Immunotherapy and immunosuppression in myeloid leukemia
Hallner A
Dissertation thesis
ISBN: 978-91-7833-201-4
Co-supervisor: Thorén FB
Full text

Cytomegalovirus Serostatus Affects Autoreactive NK Cells and Outcomes of IL2-Based Immunotherapy in Acute Myeloid Leukemia.
Bernson E, Hallner A, Sander FE, Nicklasson M, Nilsson MS, Christenson K, Aydin E, Liljeqvist JÅ, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén FB.
Cancer Immunol Res. 2018 Jul 6. doi: 10.1158/2326-6066.CIR-17-0711.
Pubmed              Full text @ AACR

Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of NOX2.
Kiffin R, Grauers Wiktorin H, Nilsson MS, Aurelius J, Aydin E, Lenox B, Nilsson JA, Ståhlberg A, Thorén FB, Hellstrand K, Martner A.
Front Oncol. 2018 Jun 18;8:218. doi: 10.3389/fonc.2018.00218.
Pubmed              Free full text @ Frontiers

Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells.
Wenger A, Werlenius K, Hallner A, Thorén FB, Farahmand D, Tisell M, Smits A, Rydenhag B, Jakola AS, Carén H.
Neoplasia. 2018 Jan;20(1):25-31. doi: 10.1016/j.neo.2017.10.006.
Pubmed              Free full text @ Elsevier

Impact of NK cell repertoires on immunotherapy in acute myeloid leukemia
Bernson E
Dissertation thesis
ISBN: 978-91-629-0339-8
Main supervisor: Thorén FB
Full text

Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Sander FE, Nilsson M, Rydström A, Aurelius J, Riise RE, Movitz C, Bernson E, Kiffin R, Ståhlberg A, Brune M, Foà R, Hellstrand K, Thorén FB, Martner A.
Cancer Immunol Immunother. 2017 Nov;66(11):1473-1484. doi: 10.1007/s00262-017-2040-9.
Pubmed              Free full text @ CII

Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia.
Bernson E, Hallner A, Sander FE, Wilsson O, Werlenius O, Rydström A, Kiffin R, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén FB.
Leukemia. 2017 Dec;31(12):2552-2559. doi: 10.1038/leu.2017.151.
Pubmed              Free full text @ NPG

The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands.
Pesce S, Thoren FB, Cantoni C, Prato C, Moretta L, Moretta A, Marcenaro E.
Front Immunol. 2017 Apr 28;8:510. doi: 10.3389/fimmu.2017.00510. eCollection 2017.
Pubmed              Free full text @ Frontiers

NOX2-dependent immunosuppression in chronic myelomonocytic leukemia.
Aurelius J, Hallner A, Werlenius O, Riise R, Möllgård L, Brune M, Hansson M, Martner A, Thorén FB, Hellstrand K.
J Leukoc Biol. 2017 Aug;102(2):459-466. doi: 10.1189/jlb.5VMA1116-454R. Epub 2017 Mar 14.
Pubmed              Full text @ JLB

Dynamics of myeloid cell populations during relapse-preventive immunotherapy in acute myeloid leukemia.
Rydström A, Hallner A, Aurelius J, Sander FE, Bernson E, Kiffin R, Thoren FB, Hellstrand K, Martner A.
J Leukoc Biol. 2017 Aug;102(2):467-474. doi: 10.1189/jlb.5VMA1116-455R
Pubmed              Full text @ JLB

Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells.
Werlenius O, Aurelius J, Hallner A, Akhiani AA, Simpanen M, Martner A, Andersson P-O, Hellstrand K, Thorén FB.
Oncotarget. 2016, doi: 10.18632/oncotarget.8769
Pubmed           Free full text @ Oncotarget

Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia.
Sander FE, Rydström A, Bernson E, Kiffin R, Riise R, Aurelius J, Anderson H, Brune M, Foà R, Hellstrand K, Thorén FB, Martner A.
Oncotarget. 2016 Feb 16;7(7):7586-96.
Pubmed           Free full text @ Oncotarget

Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia
Martner A, Rydstrom A, Riise RE, Aurelius J, Anderson H, Brune M, Foà R, Hellstrand K, Thoren FB.
Oncoimmunology. 2016, 5(1):e1041701.
Pubmed          Full text: Taylor & Francis

NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance.
Martner A, Rydström A, Riise RE, Aurelius J, Brune M, Foà R, Hellstrand K, Thorén FB.
Oncotarget. 2015 Dec 15;6(40):42569-74. doi: 10.18632/oncotarget.5559.
Pubmed          Free Full text @ Oncotarget

Opposing effects of immunotherapy in melanoma using multisubtype interferon-alpha – can tumor immune escape after immunotherapy accelerate disease progression?
Strannegard O, Thoren FB.
Oncoimmunology.2015, 5(3): e1091147
Pubmed          Free full text: Taylor & Francis             Free Full text

Immune escape in chronic leukemia
Werlenius O
Dissertation thesis
ISBN: 978-91-628-9528-0
Main supervisor: Thorén FB
Full text

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.
Riise RE, Bernson E, Aurelius J, Martner A, Pesce S, Della Chiesa M, Marcenaro E, Bylund J, Hellstrand K, Moretta L, Moretta A, Thorén FB.
J Immunol. 2015 Aug 1;195(3):1121-8. doi: 10.4049/jimmunol.1500709.
Pubmed          Full text: J Immunol

On the role of innate cell interactions in inflammation and leukemia
Riise RE
Dissertation thesis
Main supervisor: Thorén FB
Full text

Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase.
Martner A, Wiktorin HG, Lenox B, Ewald Sander F, Aydin E, Aurelius J, Thorén FB, Ståhlberg A, Hermodsson S, Hellstrand K.
J Immunol. 2015 May 15;194(10):5014-21. doi: 10.4049/jimmunol.1402991.
Pubmed          Full text: J Immunol       Free PMC Article

Immunotherapy with histamine dihydrochloride and low-dose interleukin-2 favors sustained lymphocyte recovery in acute myeloid leukemia.
Hallner A, Aurelius J, Thorén FB, Sander FE, Brune M, Hellstrand K, Martner A.
Eur J Haematol. 2015 Mar;94(3):279-80. doi: 10.1111/ejh.12454.
Pubmed          Full text: Eur J Haematol            Free full text

Accumulation of regulatory T cells during immunotherapy does not increase relapse risk in acute myeloid leukemia.
Martner, A., Rydstrom, A., Ewald, F., Riise, R.E., Aurelius, J., Brune, M., Foa, R., Hellstrand, K. & Thoren, F.B.
Blood, E-letter, 2014

CD20 antibodies induce production and release of reactive oxygen species by neutrophils.
Werlenius, O., Riise, R., Simpanen, M., Aurelius, J., Thoren, F.B.
Blood. 2014;123(25):4001
Pubmed               Full text – Blood                Free full text

Role of the ERK Pathway for Oxidant-Induced Parthanatos in Human Lymphocytes.
Akhiani, A.A., Werlenius, O., Aurelius, J., Movitz, C., Martner, A., Hellstrand, K. & Thoren, F.B.
PLoS One 9,e89646(2014)
Pubmed              Free full text – PLoS One

Late divergence of survival curves in cancer immunotherapy trials: interpretation and implications.
Thoren, F.B., Anderson, H. & Strannegard, O.
Cancer Immunol Immunother. 2013;62:1547
Pubmed             Full text – CII            Free full text

Immunotherapeutic strategies for relapse control in acute myeloid leukemia.
Martner, A., Thoren, F.B., Aurelius, J. & Hellstrand, K.
Blood Rev 2013;27:209
Pubmed            Full text – Blood Rev      Free full text

A simple skin blister technique for the study of in vivo transmigration of human leukocytes.
Davidsson, L., Bjorkman, L., Christenson, K., Alsterholm, M., Movitz, C., Thoren, F.B., Karlsson, A., Welin, A. & Bylund, J.
J Immunol Methods 2013;393:8
Pubmed        Full text – J Immunol Methods

Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes.
Aurelius, J., Martner, A., Riise, R.E., Romero, A.I., Palmqvist, L., Brune, M., Hellstrand, K. & Thoren, F.B. J Leukoc Biol 93, 155-160 (2013)
Pubmed        Free full text – J Leuk Biol.

Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells.
Aurelius, J., Martner, A., Brune, M., Palmqvist, L., Hansson, M., Hellstrand, K. & Thoren, F.B.
Haematologica 2012;97:1904
Pubmed        Free full text – Haematologica

Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of apoptosis.
Aurelius, J., Thoren, F.B., Akhiani, A.A., Brune, M., Palmqvist, L., Hansson, M., Hellstrand, K. & Martner, A.
Blood 2012;119:5832
Pubmed        Free full text – Blood

Analyzing cell death events in cultured leukocytes.
Christenson, K., Thoren, F.B. & Bylund, J.
Methods in Molecular Biology 844, 65-86 (2012).
Pubmed       Full text – Springer      Free full text

Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism.
Thoren, F.B., Riise, R.E., Ousback, J., Della Chiesa, M., Alsterholm, M., Marcenaro, E., Pesce, S., Prato, C., Cantoni, C., Bylund, J., Moretta, L. & Moretta, A.
J Immunol 188, 1668-1674 (2012).
Pubmed       Full text: J Immunol

Redox Remodeling by Dendritic Cells Protects Antigen-Specific T Cells against Oxidative Stress.
Martner, A., Aurelius, J., Rydstrom, A., Hellstrand, K. & Thoren, F.B. J Immunol 187, 6243-6248 (2011).
Pubmed       Full text – J Immunol

Adjuvant interferon: extended follow-up times needed?
Thoren, F.B. & Strannegard, O.
Lancet Oncol 12, 419 (2011).
Pubmed       Free full text – Lancet

Age-Related Efficacy of Immunotherapy with Histamine Dihydrochloride and Interleukin-2 for Relapse Prevention in Acute Myeloid Leukemia.
Hellstrand, K., Thoren, F.B., Martner, A., Soderholm, J., Hofmann, W.K., Rowe, J.M. & Brune, M.
Ann Hematol 90, S30-S32 (2011).

Antitumor properties of histamine in vivo.
Thoren, F.B., Aurelius, J. & Martner, A.
Nature medicine 17, 537 (2011).
Pubmed       Full text – Nature         Free full text

The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor 1.
Thoren, F.B., Karlsson, J., Dahlgren, C. & Forsman, H.
Biochem Pharmacol 80, 389-395 (2010).
Pubmed       Full text – Elsevier

[The discussion about Multiferon should go on].
Strannegard, O. & Thoren, F.B.
Lakartidningen 107, 3227; discussion 3227 (2010).
Pubmed       Free full text – Läkartidningen

[Underutilization of anticancer agents–an example].
Strannegard, O. & Thoren, F.B.
Lakartidningen 107, 3150; discussion 3150-3151 (2010).
Pubmed       Free full text – Läkartidningen

Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia.
Martner, A., Thoren, F.B., Aurelius, J., Soderholm, J., Brune, M. & Hellstrand, K.
Expert Rev Hematol 3, 381-391 (2010).
Pubmed       Full text – Taylor & Francis

Histamine dihydrochloride and low-dose interleukin-2 as post-consolidation immunotherapy in acute myeloid leukemia.
Thoren, F.B., Romero, A.I., Brune, M. & Hellstrand, K.
Expert Opin Biol Ther 9, 1217-1223 (2009).
Pubmed         Full text      Free full text

Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 in AML.
Romero, A.I., Thoren, F.B., Aurelius, J., Askarieh, G., Brune, M. & Hellstrand, K.
Scand J Immunol 70, 194-205 (2009).
Pubmed        Full text – SJI       Free full text

[Interferon-alpha can improve the prognosis in high-risk melanoma. Combination of surgery, cytostatics and natural IFN-alpha doubled the survival rate].
Strannegard, O., Thoren, F.B. & Lundgren, E.
Lakartidningen 105, 358-361 (2008).
Pubmed         Free full text – Läkartidningen

The CD16-/CD56bright subset of NK cells is resistant to oxidant-induced cell death.
Thoren, F.B., Romero, A.I., Hermodsson, S. & Hellstrand, K.
J Immunol 179, 781-785 (2007).
Pubmed         Free full text – JI

Cutting edge: Antioxidative properties of myeloid dendritic cells: protection of T cells and NK cells from oxygen radical-induced inactivation and apoptosis.
Thoren, F.B., Betten, A., Romero, A.I. & Hellstrand, K.
J Immunol 179, 21-25 (2007).
Pubmed         Free full text – JI

Oxygen radicals induce poly(ADP-ribose) polymerase-dependent cell death in cytotoxic lymphocytes.
Thoren, F.B., Romero, A.I. & Hellstrand, K.
J Immunol 176, 7301-7307 (2006).
Pubmed         Free full text – JI

Long-term survival benefit after adjuvant treatment of cutaneous melanoma with dacarbazine and low dose natural interferon alpha: A controlled, randomised multicentre trial.
Stadler, R., Luger, T., Bieber, T., Kohler, U., Linse, R., Technau, K., Schubert, R., Schroth, K., Vakilzadeh, F., Volkenandt, M., Gollnick, H., Von Eick, H., Thoren, F. & Strannegard, O.
Acta Oncol 45, 389-399 (2006).
Pubmed         Full text

NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen species.
Romero, A.I., Thoren, F.B., Brune, M. & Hellstrand, K.
Br J Haematol 132, 91-98 (2006).
Pubmed         Full text

Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMN.
Itou, T., Collins, L.V., Thoren, F.B., Dahlgren, C. & Karlsson, A.
Clin Vaccine Immunol 13, 575-583 (2006).
Pubmed         Free full text – CVI

A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions.
Bellner, L., Thoren, F., Nygren, E., Liljeqvist, J.A., Karlsson, A. & Eriksson, K.
J Immunol 174, 2235-2241 (2005).
Pubmed         Free full text JI

Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP 104).
Asemissen, A.M., Scheibenbogen, C., Letsch, A., Hellstrand, K., Thoren, F., Gehlsen, K., Schmittel, A., Thiel, E. & Keilholz, U.
Clin Cancer Res 11, 290-297 (2005).
Pubmed        Free full text – AACR

Activation of cytotoxic lymphocytes by interferon-{alpha}: role of oxygen radical-producing mononuclear phagocytes.
Hansson, M., Romero, A., Thoren, F., Hermodsson, S. & Hellstrand, K.
J Leukoc Biol 76, 1207-1213 (2004).
Pubmed       Free full text – JLB

A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals.
Thoren, F., Romero, A., Lindh, M., Dahlgren, C. & Hellstrand, K.
J Leukoc Biol 76, 1180-1186 (2004).

Pubmed       Free full text – JLB